AGROALNEXT PARABIOTICS Project: Application of paraprobiotic and postbiotic agents in the prevention and treatment of obesity. Mechanisms involved.
- Type Project
- Scope Autonómico
- Autonomous community Navarra, Comunidad Foral de
- Main source of financing NextGenerationEU
- Project website Web del Proyecto
Description
PARABIOTICS proposes the identification and functional characterization of probiotic strains that, either in inactivated form or through their metabolites (called postbiotics), are able to improve parameters related to obesity, such as excess weight, adiposity, insulin resistance or inflammation, thus replacing the use of their active forms (or probiotics).
Description of activities
Research studies conducted in recent years have highlighted the important role of the gut microbiota in host health. In the case of overweight and obesity, obese individuals have been observed to have alterations in the composition of their gut microbiota (dysbiosis), with physiological and metabolic consequences. One of the mechanisms by which the gut microbiota appears to affect host metabolism is mediated by certain metabolites from the microbial digestion of some nutrients or dietary ingredients, known as postbiotic agents, which have biological activity.
Results
Development of different inactivation methodologies for probiotic strains, with varying effects on their efficacy. Functional evaluation using various in vitro and in vivo models (C. elegans and obese rodents) allowed for the identification of beneficial properties of these postbiotics. Parallel toxicology studies confirmed the safety of the inactive forms. Filing of 3 patent applications: EP24383384.5, EP25382355.3 and EP25382189.6. Implementation of a clinical trial to study the effects of a postbiotic administered in gummy form in obese individuals.
Contact information
- Coordinator/entity name: Paula Aranaz
- Mailing address: Not available
- Email coordinator/entity: paranaz@unav.es
- Phone: Not available
Coordinators
- UNAV
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