INMUNOGEN Operational Group: Integration of immunocompetence marker-assisted genetic selection into dairy and beef cattle selection programs
- Type Operational group
- Status In progress
- Execution 2024 -2027
- Assigned Budget 506.703,00 €
- Scope Supraautonómico
- Autonomous community Castilla y León; Madrid, Comunidad de
- Main source of financing PEPAC 2023-2027
- Project website GO INMUNOGEN
The GO_INMUNOGEN project has a potentially transformative impact on the livestock sector in Spain. By improving the resistance of animals to bovine paratuberculosis (PTB) and their general immunocompetence, the need for antibiotic treatments will be reduced, the longevity of animals will be increased and productive efficiency will be improved. This will benefit thousands of farmers and strengthen the competitiveness of the sector. Consequently, this project aims to advance towards sustainable and efficient cattle farming through the use of genetic markers that allow the evaluation and improvement of susceptibility, resistance and tolerance to PTB in breeding programs.
GO_INMUNOGEN is driving the livestock sector toward a more sustainable and competitive future by improving animal health and disease resistance through marker-assisted genetic selection. Its focus on PTB has the potential to benefit livestock farmers and contribute to sustainable agricultural development and food security.
- Project Writing and Management.
- Development of the Computer Tool.
- Categorization of the most influential animal genotypes.
- Routine categorization of new genotypes.
- Transfer of the Tool to CONAFE.
- Genotyping of Friesian animals for categorization and preselection; design of the sampling process.
- Quantification of bacterial load in macrophages and gamma interferon in the blood of 100 ABEREKIN bulls of different breeds.
- Genotyping of animals of other breeds for preselection.
- Categorization of animals of other breeds.
- Laboratory analysis and validation (Interferon gamma (IFN?)).
- Laboratory analysis and validation (Reduction of bacterial load inside the infected macrophage). Laboratory analysis and validation (Interferon gamma (IFN?)) in animals of other breeds.
- Laboratory analysis and validation (Reduction of load inside the infected macrophage) in animals of other breeds.
- GWAS Analysis; Integration of Results into Databases; and Project Management.
- Project presentation.
- Major: To advance sustainable and efficient cattle farming through the use of genetic markers that allow for the evaluation and improvement of susceptibility, resistance, and tolerance to Paratuberculosis in breeding programs.
- Specific objectives:
- Advanced Computing Tool: Develop a platform to assess susceptibility, tolerance, and resistance to bovine paratuberculosis (BPT).
- Validation in Different Breeds: Conduct tests on Friesian, Brown, and Limousin breeds to ensure the tool's effectiveness and improve it.
- Advanced Computing Tool: A platform will be created to evaluate susceptibility, tolerance, and resistance to bovine paratuberculosis (BPT) in cattle.
- Rigorous Validation: The tool's effectiveness will be verified in animals of different breeds, ensuring its applicability in various livestock farms.
- Reliable Predictive Models: Predictive models will be developed to categorize animals based on their ability to combat PTB.
- Impact on Animal Health: The immunocompetence of animals will be improved not only against PTB but also against other diseases, reducing the need for antibiotic treatment.
- Coordinator/entity name: CONFEDERATION OF SPANISH FRIESSIAN ASSOCIATIONS - CONAFE
- Postal Address: Carretera de Andalucía km 23.600. 28320 Pinto, Spain
- Coordinator/entity email: sofia.alday@conafe.com
- Telephone: +34 918952412
- CONFEDERACION DE ASOCIACIONES DE FRISONA ESPAÑOLA - CONAFE
- CONFEDERACION DE ASOCIACIONES DE FRISONA ESPAÑOLA - CONAFE
- ASOCIACION DE RAZA PARDA - ARAPAR
- FEDERACION ESPAÑOLA DE CRIADORES DE LIMUSIN - F.E.C.L
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